Access to Louisiana & Pike County: From St. Louis via interstate 70 West to U.S. highway 61 North / 55 miles, exit onto U.S. highway 54 east 10 miles to Louisiana. --- From Kansas City via interstate 70 East through Columbia to U.S. highway 54 East, follow U.S. 54 to Louisiana. --- From Chicago, IL via interstate 55 South to interstate 72 West exiting Pittsfield, IL exit & U.S. highway 54 West 25 miles crossing the Mississippi entering Louisiana.